Asymmetric Septal Hypertrophy and Myocardial Fiber Disarray
نویسنده
چکیده
The specificity and significance of the asymmetric septal hypertrophy (ASH) and myocardial fiber disarray of idiopathic hypertrophic subaortic stenosis (IHSS) is uncertain. To examine this we studied 215 hearts, including normal embryos, fetuses, children, and adults; and hearts with congenital and acquired disease. Disproportionate septal thickening was present in all embryos and in some abnormal hearts, particularly those with severe right ventricular hypertrophy due to congenital malformations. Some myocardial fiber disarray was present in all hearts at the junctions of in-
منابع مشابه
Myocardial fiber disarray and ventricular septal hypertrophy in asymmetrical hypertrophy of the heart.
ALTHOUGH TWO NINETEENTH CENTURY French pathologists1 2 and an early twentieth century German pathologist3 described cardiac pathological findings compatible with what we know today as "6asymmetrical hypertrophy of the heart," it remained for Donald Teare to bring attention to this entity in 1958.4 In nine cases of sudden death, Teare described a marked hypertrophy and thickening of the interven...
متن کاملExtensive myocardial fiber disarray in aortic and pulmonary atresia. Relevance to hypertrophic cardiomyopathy.
Myocardial fiber disarray is a distinctive histopathologic finding seen in asymmetric hypertrophic cardiomyopathy. We studied 14 hearts with aortic atresia and intact interventricular septum, six hearts with pulmonic atresia and intact interventricular septum, eight normal infant hearts matched for age of the study hearts, and one nonadult heart with hypertrophic cardiomyopathy and asymmetric h...
متن کاملCatenoid shape of the interventricular septum: possible cause of idiopathic hypertrophic subaortic stenosis.
Previous studies have shown that asymmetric septal hypertrophy (ASH) may occur in embryonic and malformed hearts and that muscle cell disarray is found in myocardium that contracts isometrically. To account for the characteristic ASH and septal muscle fiber disarray of idiopathic hypertrophic subaortic stenosis (IHSS), we postulated that a catenoid shape of the septum, i.e., net zero curvature,...
متن کاملMyocardial fascicle and fiber disarray in 25 mu-thick sections.
We compared the histologic picture of myocardial fiber disarray in thin (4 mu) and thick (25 mu) sections of tissues obtained at autopsy from 18 adults and eight infants with clinically normal hearts, from 10 hearts with concentric hypertrophy (hypertensive patients), nine with myocardial infarction and four with hypertrophic cardiomyopathy (HCM). In the thick sections, so-called bizarre myocar...
متن کاملRegional septal dysfunction in a three-dimensional computational model of focal myofiber disarray.
MLC2v/ras transgenic mice display a phenotype characteristic of hypertrophic cardiomyopathy, with septal hypertrophy and focal myocyte disarray. Experimental measurements of septal wall mechanics in ras transgenic mice have previously shown that regions of myocyte disarray have reduced principal systolic shortening, torsional systolic shear, and sarcomere length. To investigate the mechanisms o...
متن کامل